When psychological stress causes cortisol levels to increase in your system, so does the amount of glucose, a blood sugar. Unused glucose is stored as fat.
The logic seems straightforward: blocking cortisol should help people lose weight.
Is this true?
Yes and no.
It’s true that the adrenal cortex of people who suffer from Cushing’s Syndrome, a hormonal disorder, produces huge amounts of cortisol, causing them to gain weight in their faces, trunks, and abdomens.
But there’s a catch to the claim that cortisol blockers can cause people to lose weight. Psychological stress doesn’t produce nearly enough cortisol to cause fat deposits.
Wellness expert Dr. Andrew Weil says cortisol in amounts high enough to cause fat deposits can only be produced as the side effect of some medicines or by Cushing’s Syndrome.
Dr. Weil cites Dr. Seymour Reichlin, an endocrinologist and retired research professor at the University of Arizona, who says no scientific studies have proven that the amount of cortisol produced by healthy people is large enough to end up as fat deposits.

Are cortisol blockers good diet drugs?

Georgiahealthinfo, a health service in Georgia, says no reliable evidence exists that so-called “cortisol blockers” actually block cortisol, or if they do, that they help people lose weight.
In 2007, the Federal Trade Commission charged the manufacturers of two popular brands of cortisol blockers with making false and unsubstantiated claims that their products can help people lose weight. The companies were forced to refund millions of dollars to consumers and were prevented from making weight loss claims.

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